論文

 

2024

 

Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats.

Satoru Takeshita, Hiroki Kakita, Nami Nakamura, Mari Mori, Kohki Toriuchi, Hiromasa Aoki, Yasumichi Inoue, Hidetoshi Hayashi, Yasumasa Yamada, Mineyoshi Aoyama.

Experimental Neurology. in press.

 

ID3 is a novel target gene of p53 and modulates lung cancer cell.

Mai Nagasaka , Chiharu Miyajima, Sakura Hashiguchi, Yuya Suzuki, Daisuke Morishita , Hiromasa Aoki, Kohki Toriuchi, Ryohei Katayama, Mineyoshi Aoyama, Hidetoshi Hayashi.

Biochemical and Biophysical Research Communications. in press.

 

2023

 

SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner.

Nagasaka M, Inoue Y, Nagao Y, Miyajima C, Morishita D, Aoki H, Aoyama M, Imamura T, Hayashi H.

Sci Rep. in press.

 

Hypothermia attenuates neurotoxic microglial activation via TRPV4.

Fukuda N*, Toriuchi K*, Mimoto R, Aoki H, Kakita H, Suzuki Y, Takeshita S, Tamura T, Yamamura H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.

Neurochem Res. in press.

 

Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation, and proteasomal degradation.

Tokugawa M, Inoue Y, Aoki H, Miyajima C, Ishiuchi K, Tsurumi K, Kujirai C, Morishita D, Matsuno M, Mizukami H, Ri M, Iida S, Makino T, Aoyama M, Hayashi H.

J. Biochem. in press.

 

AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway. 

Owaki R*, Aoki H*, Toriuchi K, Inoue Y, Hayashi H, Takeshita S, Kakita H, Yamada Y, Aoyama M.

Exp Cell Res. 2023; 432(1):113784.

 

Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly: A case report.

Mori M, Takeshita S, Nakamura N, Mizuno Y, Tomita A, Aoyama M, Kakita H, Yamada Y. 

World J Clin Cases. 2023; 11(26): 6262-6267.

 

Reovirus combined with a STING agonist enhances anti‑tumor immunity in a mouse model of colorectal cancer.

Sugimura N, Kubota E, Mori Y, Aoyama M, Tanaka M, Shimura T, Tanida S, Randal N.J, Kataoka H.

Cancer Immunol. Immunother. 2023; 72(11):3593-3608.

 

Successful noninvasive respiratory management of an infant with bilateral choanal atresia

and a supernumerary nostril located on the columella by a mouthpiece: A case report.

Nakamura N, Kakita H, Takagi M, Asai S, Asai T, Mori M, Takeshita S, Ueda H, Aoyama M, Kishimoto M, Ito K, Yamada Y.

Am. J. Case Rep. 2023 Jun 26:24:e939642.

 

The DNMT3B inhibitor nanaomycin A as a neuroblastoma therapeutic agent.

Izumi K, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Yamada Y,  Aoyama M.

Curr. Cancer Drug Targets. 2023;23(11):837-842.

 

Monocyte-derived miRNA-1914-5p attenuates IL-1β-induced monocyte adhesion and transmigration.

Toriuchi K*, Kihara T*, Aoki H, Kakita H, Takeshita S, Ueda H, Yamada Y, Aoyama M.

Int. J. Mol. Sci. 2023;24(3):2829.

 

The combination of ATM and Chk1 inhibitors induces synthetic lethality in colorectal cancer cells.

Tozaki Y*, Aoki H*, Kato R, Toriuchi K, Arame S, Inoue Y, Hayashi H, Kubota E, Kataoka H, Aoyama M.

Cancers. 2023;15(3):735.

 

Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco-2 cells.

Shimizu Y, Koizumi K, Tsutsumi T, Kyogashima M, Kannagi R, Iwaki S, Aoyama M, Tokumura A.

Lipids. 2023;58(2):93-103.

 

IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells.

Otsuka Y, Kondo T, Aoki H, Goto Y, Kawaguchi Y, Waguri-Nagaya Y, Miyazawa K, Goto S, Aoyama M.

J Pharmacol Sci. 2023;151(1)1-8.

 

2022

 

Generation of brain microvascular endothelial-like cells from human iPS cell-derived endothelial progenitor cells using the TGF-β receptor inhibitor, laminin 511 fragment, and neuronal cell culture supplements.

Aoki H*, Yamashita M*, Hashita T, Iwao T, Aoyama M, Matsunaga T.

Pharmaceutics. 2022;14(12):2697.

 

Insights into regulators of p53 acetylation.

Nagasaka M, Miyajima C, Aoki H, Aoyama M, Morishita D, Inoue Y, Hayashi H. 

Cells. 2022;11(23):3825.

  

Hyperglycemia and lactic acidosis associated with linezolid therapy in an extremely premature infant.

Asai T, Kakita H, Nakamura N, Asai S, Mori M, Takeshita S, Ueda H, Mizuno Y, Tomita A, Aoyama M, Yamada Y.

Neonatology. 2022;30:1-4.

 

Thrombocytopenia and insufficient thrombopoietin production in human small-for-gestational-age infants.

Takeshita S, Kakita H, Asai S, Asai T, Mori M, Ueda H, Aoki H, Aoyama M, Yamada Y.

Pediatr Res. In press.

 

Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells.

Tamiya-Koizumi K, Otoki Y, Nakagawa K, Kannagi R, Mizutani N, Suzuki M, Kyogashima M, Iwaki S, Aoyama M, Murate T, Kitatani K, Kuga T, Mizutani Y.

Biochem Biophys Res Commun. 2022;611:1-7.

 

Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia.

Kondo T, Aoki H, Otsuka Y, Kawaguchi Y, Waguri-Nagaya Y, Aoyama M.

J Pharmacol Sci. 2022;149(3):93-99.

 

Photodynamic therapy using mannose-conjugated chlorin e6 increases cell surface calreticulin in cancer cells and promotes macrophage phagocytosis.

Kimura Y*, Aoki H*, Soyama T, Sakuragi A, Otsuka Y, Nomoto A, Yano S, Nishie H, Kataoka H, Aoyama M.

Med Oncol. 2022;39(5):82.

 

The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes.

Joyo Y, Kawaguchi Y, Yonezu H, Senda H, Yasuma S, Shiraga H, Nozaki M, Aoyama M,  Asai K , Murakami H, Waguri‑Nagaya Y.

Immunol Res. 2022;70(2):208-215..

 

 

2021

 

The inducible nitric oxide synthase pathway promotes osteoclastogenesis under hypoxic culture conditions.

Kondo T, Otsuka Y, Aoki H, Goto Y, Kawaguchi Y, Waguri-Nagaya Y, Miyazawa K, Goto S, Aoyama M.

Am J Pathol. 2021;191(12):2072-2079.

 

Interleukin-1β enhances cell adhesion in human endothelial cells via microRNA-1914–5p suppression.

Kihara T*, Toriuchi K*, Aoki H, Kakita H, Yamada Y, Aoyama M.

Biochem Biophys Rep. 2021;27:101046.

 

Three-dimensional spheroid culture induces apical-basal polarity and parent-cell characteristics of immortalized human renal proximal tubular epithelial cells.

Mizuguchi K, Aoki H, Aoyama M, Kawaguchi Y, Waguri-Nagaya Y, Ohte N, Asai K.

Exp Cell Res. 2021;404(1):112630. 

 

Hypothermia attenuates neuronal damage via inhibition of microglial activation, including suppression of microglial cytokine production and phagocytosis. 

Kimura T*, Toriuchi K*, Kakita H, Tamura T, Takeshita S, Yamada Y, Aoyama M. 

Cell Mol Neurobuol. 2021;41(3):459-468.

 

Insufficient thrombopoietin due to hepatic dysmature results in thrombocytopenia in small-for- gestational-age rats.

Takeshita S, Kakita H, Toriuchi K, Aoki H, Ueda H, Wakatsuki A, Yamada Y, Aoyama M.

Br J Haematol. 2021;192(4):e105-e108.

 

Photodynamic therapy exploiting the anti-tumor activity of mannose-conjugated chlorin e6 reduced M2-like tumor-associated macrophages.

Soyama T, Sakuragi A, Oishi D, Kimura Y, Aoki H, Nomoto A, Yano S, Nishie H, Kataoka H, Aoyama M

Transl Oncol. 2021;14(2):101005.

 

 

2020

 

The secreted glycoprotein Reelin suppresses the proliferation and regulates the distribution of oligodendrocyte progenitor cells in the embryonic neocortex.

Ogino H, Nakajima T, Hirota Y, Toriuchi K, Aoyama M, Nakajima K, Hattori M.

J Neurosci. 2020;40(40):7625-7636.

 

IL-6 promotes cell adhesion in human endothelial cells via microRNA-126-3p suppression.

Ohta M, Kihara T, Toriuchi K, Aoki H, Iwaki S, Kakita H, Yamada Y, Aoyama M.

Exp Cell Res. 2020;393(2):112094.

 

Inhibition of transforming growth factor beta signaling pathway promotes differentiation of human induced pluripotent stem cell-derived brain microvascular endothelial-like cells.

Yamashita M, Aoki H, Hashita T, Iwao T, Matsunaga T.

Fluids Barriers CNS. 2020;17(1):36.

  

Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions.

Toriuchi K, Kakita H, Tamura T, Takeshita S, Yamada Y, Aoyama M.

J Neuroinflammation. 2020;17(1):141.

 

Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.

Aoki H*, Yamashita M*, Hashita T, Iwao T, Matsunaga T.

Fluids Barriers CNS. 2020;17(1):25.

 

Efficient differentiation and purification of human induced pluripotent stem cell-derived endothelial progenitor cells and expansion with the use of inhibitors of ROCK, TGF-β, and GSK3β. 

Aoki H, Yamashita M, Hashita T, Ogami K, Hoshino S, Iwao T, Matsunaga T.

Heliyon. 2020;6(3):e03493.

 

 

2019

 

Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures. 

Aoki H, Yamashita M, Hashita T, Nakayama M, Yagi M, Iwao T, Matsunaga T.

Biochem Biophys Res Commun. 2019;515(4):672-678.

 

Active Phagocytosis and Diachronic Processing of Calcium Oxalate Monohydrate Crystals in an in vitro Macrophage Model. 

Okada A, Aoki H, Onozato D, Kato T, Hashita T, Takase H, Sugino T, Unno R, Taguchi K, Hamamoto S, Ando R, Mizuno K, Tozawa K, Matsunaga T, Kohri K, Yasui T.

Kidney Blood Press Res. 2019;44(5):1014-1025

 

 

2018

Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation. 

Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M.
Biochem Biophys Res Commun. 2018;503(2):544-549.

 

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. 

Kasahara K, Aoki H, Kiyono T, Wang S, Kagiwada H, Yuge M, Tanaka T, Nishimura Y, Mizoguchi A, Goshima N, Inagaki M.

Nat Commun. 2018;9(1):758.

 

The Janus kinase inhibitor tofacitinib inhibits TNF-α-induced gliostatin expression in rheumatoid fibroblast-like synoviocytes.
Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Oguri Y, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T. 

Clin Exp Rheumatol. 2018;36(4):559-567.

 

Mithramycin has inhibitory effects on gliostatin and matrix metalloproteinase expression induced by gliostatin in rheumatoid fibroblast-like synoviocytes. 

Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Oguri Y, Ikuta K, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T.
Mod Rheumatol. 2018:1-11.

 

 

2017

Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells. 

Inagaki Y, Kubota E, Mori Y, Aoyama M, Kataoka H, Johnston RN, Joh T.
Oncotarget. 2017;8(70):115632-115646.

 

Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K. 

Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M.
Sci Rep. 2017;7:41710.

 

Neuroprotective erythropoietin attenuates microglial activation, including morphological changes, phagocytosis, and cytokine production. 

Tamura T, Aoyama M, Ukai S, Kakita H, Sobue K, Asai K.
Brain Res. 2017;1662:65-74.

 

 

2016

CXCR4+CD45- cells are niche forming for osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 signaling pathways in bone marrow. 

Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri-Nagaya Y, Miyazawa K, Asai K, Goto S.
Stem Cells. 2016;34(11):2733-2743.

 

 

2015

Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells. 

Hamano S, Mori Y, Aoyama M, Kataoka H, Tanaka M, Ebi M, Kubota E, Mizoshita T, Tanida S, Johnston RN, Asai K, Joh T.
Cancer Lett. 2015;356(2 Pt B):846-54.

 

 

2014

Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α. 

Nagaya Y, Aoyama M, Tamura T, Kakita H, Kato S, Hida H, Saitoh S, Asai K.
Eur J Neurosci. 2014;40(11):3620-6.

Prognostic impact of microRNA-145 down-regulation in adult T-cell leukemia/lymphoma. 

Xia H, Yamada S, Aoyama M, Sato F, Masaki A, Ge Y, Ri M, Ishida T, Ueda R, Utsunomiya A, Asai K, Inagaki H.
Hum Pathol. 2014;45(6):1192-8.

Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions. 

Nomura T, Aoyama M, Waguri-Nagaya Y, Goto Y, Suzuki M, Miyazawa K, Asai K, Goto S.
Exp Cell Res. 2014;321(2):167-77.

 

 

2013

Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production. 

Kakita H, Aoyama M, Nagaya Y, Asai H, Hussein MH, Suzuki M, Kato S, Saitoh S, Asai K.
Toxicol Appl Pharmacol. 2013;268(2):99-105.

Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte. Asai H, Kakita H, Aoyama M, Nagaya Y, Saitoh S, Asai K.
Cell Mol Neurobiol. 2013;33(3):393-400.

 

 

2012

Region-specific expression of a water channel protein, aquaporin 4, on brain astrocytes. 

Aoyama M, Kakita H, Kato S, Tomita M, Asai K.
J Neurosci Res. 2012;90(12):2272-80.

 

Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative. 

Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, Ikenaka K, Asai K, Togari H, Sobue K, Sawamoto K.
Stem Cells. 2012;30(10):2234-47.

The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes. 

Ikuta K, Waguri-Nagaya Y, Kikuchi K, Yamagami T, Nozaki M, Aoyama M, Asai K, Otsuka T.
Arthritis Res Ther. 2012;14(2):R87.

 

 

2011

ERas enhances resistance to CPT-11 in gastric cancer. 

Kubota E, Kataoka H, Tanaka M, Okamoto Y, Ebi M, Hirata Y, Murakami K, Mizoshita T, Shimura T, Mori Y, Tanida S, Kamiya T, Aoyama M, Asai K, Joh T.
Anticancer Res. 2011;31(10):3353-60.

Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury. 

Kato S, Aoyama M, Kakita H, Hida H, Kato I, Ito T, Goto T, Hussein MH, Sawamoto K, Togari H, Asai K.
J Neurosci Res. 2011;89(10):1566-74.

Interleukin (IL)-1 and IL-6 regulation of neural progenitor cell proliferation with hippocampal injury: differential regulatory pathways in the subgranular zone (SGZ) of the adolescent and mature mouse brain. 

McPherson CA, Aoyama M, Harry GJ.
Brain Behav Immun. 2011;25(5):850-62.

FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes. 

Yamagami T, Waguri-Nagaya Y, Ikuta K, Aoyama M, Asai K, Otsuka T.
Rheumatol Int. 2011;31(7):903-909.

 

 

2010

Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells. 

Aoyama M, Kataoka H, Kubota E, Tada T, Asai K.
Int J Oncol. 2010;37(4):1011-1016.

Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer. 

Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, Tanaka M, Sasaki M, Takahashi S, Asai K, Joh T.
Am J Pathol. 2010;177(2):955-963.

TNF-α-induced aquaporin 9 in synoviocytes from patients with OA and RA. 

Nagahara M, Waguri-Nagaya Y, Yamagami T, Aoyama M, Tada T, Inoue K, Asai K, Otsuka T.
Rheumatology (Oxford). 2010;49(5):898-906.

 

 

2009

Silicone-induced foreign-body reaction after first metatarsophalangeal joint arthroplasty for Jaccoud's arthropathy. 

Waguri-Nagaya Y, Yamagami T, Tsuchiya A, Nozaki M, Goto H, Kobayashi M, Aoyama M, Tada T, Otsuka T.
Rheumatol Int. 2009;29(11):1367-71.

Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes. 

Ohara K, Aoyama M, Fujita M, Sobue K, Asai K.
Neurosci Lett. 2009;462(2):109-12. 

Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes. 

Kakita H, Aoyama M, Hussein MH, Kato S, Suzuki S, Ito T, Togari H, Asai K.
Toxicol Appl Pharmacol. 2009;238(1):56-63.

IGF2 modulates the microenvironment for osteoclastogenesis. 

Nakao K, Aoyama M, Fukuoka H, Fujita M, Miyazawa K, Asai K, Goto S.

Biochem Biophys Res Commun. 2009;378(3):462-6.